From the Department of Neurology, Hallym University, Kangdong Sacred Heart Hospital, Seoul, Korea (Dr. W-K Kim); Department of Neurology, College of Medicine, Pochon CHA University, Seoul, Korea (Dr. H-S Kim); Departments of Neurology and Brain Korea 21 Project for Medicine Science, Yonsei University College of Medicine, Seoul, Korea (Drs. W-K Kim, Choi, and Lee); Internal Medicine, Yonsei University College of Medicine, Seoul, Korea (Dr. Park); and Psychiatry, Yonsei University College of Medicine, Seoul, Korea (Drs. C-H Kim and W-K Kim).
Serotonin Transporter Gene Polymorphism and Migraine in the Korean Population
Article first published online: 16 AUG 2005
Headache: The Journal of Head and Face Pain
Volume 45, Issue 8, pages 1056–1060, September 2005
How to Cite
Kim, W.-K., Kim, H.-S., Kim, W.-J., Lee, K.-Y., Park, H., Kim, C.-H., Kim, S. J. and Choi, Y.-C. (2005), Serotonin Transporter Gene Polymorphism and Migraine in the Korean Population. Headache: The Journal of Head and Face Pain, 45: 1056–1060. doi: 10.1111/j.1526-4610.2005.05187.x
- Issue published online: 16 AUG 2005
- Article first published online: 16 AUG 2005
- Accepted for publication March 2, 2005.
- serotonin transporter;
- serotonin transporter gene polymorphism
Objective.—To evaluate the association between a serotonin (5-HT) transporter gene polymorphism and migraines in Koreans.
Background.—The 5-HT metabolism is believed to play an important part in the pathophysiology of migraines, and a polymorphism of the serotonin transporter (5-HTT) promoter region might influence 5-HTT expression and serotonin uptake.
Methods.—This study compared 52 patients with migraine and 170 healthy control subjects in order to determine the association between a polymorphism of the 5-HTT gene-linked polymorphic region (5-HTTLPR) and migraine. Using PCR techniques, the products of the 484-base pair (bp) fragments were denoted as being short alleles (s) and those of 528 bp as being long (l).
Results.—The genotype distribution of the healthy controls was s/s (56.5%), s/l (38.2%), and l/l (5.3%) and that of the patients with migraine was 65.4%, 30.8%, and 3.8%, respectively. No significant differences were noted in the genotype and allele frequencies of 5-HTTLPR between the patients with migraine and the control subjects.
Conclusions.—A 5-HTTLPR polymorphism does not appear to be involved in the genetic predisposition to migraines.