Use of Lamotrigine in Glossopharyngeal Neuralgia: A Case Report


  • Marina Titlic MD,

  • Ivana Jukic MD,

  • Ante Tonkic MD, PhD,

  • Paula Grani PhD,

  • Jelena Jukic DDS

  • From the Department of Neurology (Dr. Titlic), Department of Internal Medicine (Drs. I. Jukic and Tonkic), Clinical Hospital Split, Split, Croatia; Clinical Institute of Laboratory Diagnosis, Clinical Hospital Center, Zagreb, Croatia (Dr. Granic); and Department of Periodontology, School of Dentistry, University of Zagreb, Zagreb, Croatia (Dr. J. Jukic).

Address all correspondence to Ivana Jukic, Department of Internal Medicine, Clinical Hospital Split, Split, Croatia.


We describe a case of a patient with glossopharyngeal neuralgia (refractory to treatment with carbamazepine, amytriptyline, diazepam, and indomethacin) treated with lamotrigine as monotherapy, the first described, who responded completely to the therapy and did not complain of side effects. The complete analgesic effect was reached at the lamotrigine daily dose of 200 mg per day and was maintained at that dose for additional 6 months, with the blood concentration within the reference range.