From the Department of Neurology, The Albert Einstein College of Medicine, Bronx, NY; The New England Center for Headache, Stamford, CT; and The Montefiore Headache Unit, Bronx, NY (Dr. Bigal); Headache Center of Rio, Rio de Janeiro, RJ, Brazil (Dr. Krymchantowski); and Department of Neurology, Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil (Dr. Krymchantowski).
Migraine Triggered by Sucralose—A Case Report
Article first published online: 21 MAR 2006
Headache: The Journal of Head and Face Pain
Volume 46, Issue 3, pages 515–517, March 2006
How to Cite
Bigal, M. E. and Krymchantowski, A. V. (2006), Migraine Triggered by Sucralose—A Case Report. Headache: The Journal of Head and Face Pain, 46: 515–517. doi: 10.1111/j.1526-4610.2006.00386_1.x
- Issue published online: 21 MAR 2006
- Article first published online: 21 MAR 2006
- Accepted for publication November 10, 2005.
Sucralose is the active compound of the most commonly sold sweetener in the United States. Different than aspartame, sucralose is not considered to be a migraine trigger. Herein we report a patient with attacks of migraine consistently triggered by sucralose. She also suffers from menstrually related migraine that had been well-controlled for several months since she switched her contraceptive from fixed estrogen to triphasic contraceptive pills. Some attacks triggered by sucralose were preceded by aura, and she had never experienced migraine with aura before. Withdrawal of the compound was associated with complete resolution of the attacks. Single-blind exposure (vs. sugar) triggered the attacks, after an attack-free period.