From Harvard Medical School and the John R. Graham Headache Centre, Brigham and Women's/Faulkner Hospital, Boston, MA.
Biomarkers in Migraine: Their Promise, Problems, and Practical Applications
Version of Record online: 6 JUL 2006
Headache: The Journal of Head and Face Pain
Volume 46, Issue 7, pages 1046–1058, July/August 2006
How to Cite
Loder, E. and Rizzoli, P. (2006), Biomarkers in Migraine: Their Promise, Problems, and Practical Applications. Headache: The Journal of Head and Face Pain, 46: 1046–1058. doi: 10.1111/j.1526-4610.2006.00498.x
- Issue online: 6 JUL 2006
- Version of Record online: 6 JUL 2006
- Accepted for publication May 4, 2006.
Biomarkers are physical signs or laboratory measurements that “occur in association with a pathological process and have putative diagnostic and/or prognostic utility.” Biomarkers hold considerable promise for understanding and intervening in the disease process of migraine. They may permit recognition of individuals at risk of developing migraine, improve the timing, accuracy, and precision of migraine diagnosis, and serve as indicators of treatment response and disease progression. Furthermore, they hold great promise for research. At the same time, there are important limitations to the use of biomarkers in migraine, including problems with validity, reliability, accuracy, and precision. Legal, ethical, and cost considerations are also important. This review describes the potential uses and limitations of biomarkers in migraine diagnosis, treatment, and research.