From the Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands (Ms. De Vries, Dr. Frants, and Dr. Van den Maagdenberg); Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands (Drs. Haan, Van den Maagdenberg, and Ferrari); Department of Neurology, Rijnland Hospital, Leiderdorp, The Netherlands (Dr. Haan).
Genetic Biomarkers for Migraine
Article first published online: 6 JUL 2006
Headache: The Journal of Head and Face Pain
Volume 46, Issue 7, pages 1059–1068, July/August 2006
How to Cite
De Vries, B., Haan, J., Frants, R. R., Van den Maagdenberg, A. M.J.M. and Ferrari, M. D. (2006), Genetic Biomarkers for Migraine. Headache: The Journal of Head and Face Pain, 46: 1059–1068. doi: 10.1111/j.1526-4610.2006.00499.x
- Issue published online: 6 JUL 2006
- Article first published online: 6 JUL 2006
- Accepted for publication May 5, 2006.
- genetic biomarkers
Biomarkers are physical signs or laboratory measurements that occur in association with a pathological process and have putative diagnostic and/or prognostic utility. In migraine, clinical, radiological, and biochemical biomarkers might be helpful to improve diagnosis, get insight in pathophysiology, and facilitate treatment choices. Genetic biomarkers are defined as genetic variations (mutations or polymorphisms) that can predict disease susceptibility, disease outcome, or treatment response. As yet, only a few genetic biomarkers for migraine are available. Mutations in 3 different genes responsible for familial hemiplegic migraine, a monogenetic subtype of migraine with aura, and the MTHFR C677T polymorphism in common forms of migraine are clear examples. Many positive findings from linkage studies and association studies in common forms of migraine have not been replicated, and are therefore of less clinical use. In this review, we will discuss genetic biomarkers in migraine.