From the Department of Medicine, Clinical Sciences, University Hospital, Lund, Sweden.
Neuronal Signal Substances as Biomarkers of Migraine
Article first published online: 6 JUL 2006
Headache: The Journal of Head and Face Pain
Volume 46, Issue 7, pages 1088–1094, July/August 2006
How to Cite
Edvinsson, L. (2006), Neuronal Signal Substances as Biomarkers of Migraine. Headache: The Journal of Head and Face Pain, 46: 1088–1094. doi: 10.1111/j.1526-4610.2006.00502.x
- Issue published online: 6 JUL 2006
- Article first published online: 6 JUL 2006
- Accepted for publication May 5, 2006.
- neuronal signal substances;
- primary headaches
Of the sensory nervous system associated signal substances it is only calcitonin generelated peptide (CGRP) that is reliably associated with the degree of pain in the acute attacks of primary headaches. The treatment with triptans alleviates both the pain and the associated CGRP release, putatively via a presynaptic effect on the sensory nerves. The studies of opoids and other sensory neuropeptides are inconsistent and require further analysis. Initial positive data on endothelin and its receptors have turned out negative. Nitric oxide mechanisms are still debated both in terms of initiation of attacks and for the treatment.