From Harvard Medical School, Graham Headache Centre, Boston, MA.
Menstrual Migraine: Pathophysiology, Diagnosis, and Impact
Article first published online: 13 OCT 2006
Headache: The Journal of Head and Face Pain
Volume 46, Issue Supplement s2, pages S56–S61, October 2006
How to Cite
Loder, E. W. (2006), Menstrual Migraine: Pathophysiology, Diagnosis, and Impact. Headache: The Journal of Head and Face Pain, 46: S56–S61. doi: 10.1111/j.1526-4610.2006.00555.x
- Issue published online: 13 OCT 2006
- Article first published online: 13 OCT 2006
The incidence of migraine varies over the course of the menstrual cycle. In the general population, approximately 60% of women with migraine report an increased frequency of headache during menses. The estrogen withdrawal that occurs just prior to the onset of menses and that leads to loss of serotonergic tone is thought to be the trigger for headaches that arise at this time of the menstrual cycle. The ability of triptans, specific serotonin receptor agonists, to prevent menstrual migraine is consistent with this hypothesis. Moreover, compared with headaches that occur during other times in the cycle, menstrual migraines are more severe in most women and may be of longer duration, as well as more resistant to treatment in a subset of women.