From the Department of Clinical and Experimental Medicine, Pediatrics, University of Ferrara, Ferrara, Italy (Drs. Soriani, Fiumana, Pedretti, and Borgna-Pignatti); Department of Clinical and Experimental Medicine, Divisions of Pediatrics and Internal Medicine, University of Ferrara, Ferrara, Italy (Drs. Manfredini and Boari); and Department of Pediatrics, University of Padua, Padua, Italy (Drs. Battistella and Canetta).
Circadian and Seasonal Variation of Migraine Attacks in Children
Version of Record online: 9 NOV 2006
Headache: The Journal of Head and Face Pain
Volume 46, Issue 10, pages 1571–1574, November/December 2006
How to Cite
Soriani, S., Fiumana, E., Manfredini, R., Boari, B., Battistella, P. A., Canetta, E., Pedretti, S. and Borgna-Pignatti, C. (2006), Circadian and Seasonal Variation of Migraine Attacks in Children. Headache: The Journal of Head and Face Pain, 46: 1571–1574. doi: 10.1111/j.1526-4610.2006.00613.x
- Issue online: 9 NOV 2006
- Version of Record online: 9 NOV 2006
- Accepted for publication May 30, 2006.
- circadian rhythm;
Object.—To investigate the rhythmicity of migraine episodes without aura in a pediatric population.
Methods.—Time of occurrence of 2517 migraine attacks in 115 children was recorded, by means of a diary, both by hourly and monthly intervals.
Results.—A significant circadian variation, characterized by a peak in the afternoon (P < .001) and one in the early morning (P= .002) was found. A seasonal peak was also observed between November and January, while a nadir was observed in July.
Conclusions.—The clustering of attacks in the morning and midday and in autumn-winter, with a minimum frequency in July, suggests that school activities may represent an important cause of migraine.