Chronic Daily Headache in Hereditary Hemochromatosis Treated by Venesection


  • Charly Gaul MD,

  • Patrick Krummernerl MD,

  • Beate Tamke MD,

  • Malte Kornhuber MD

  • From the Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle, Germany (Drs. Gaul, Kornhuber); Department of Anesthesiology, Martin-Luther-University Halle-Wittenberg, Halle, Germany (Dr. Tamke); Department of Internal Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany (Dr. Krummernerl).

Address all correspondence to Dr. Charly Gaul, Department of Neurology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, D-06097 Halle (Saale), Germany.


Coincidence or causality between iron overload and headaches (e.g., daily headache, migraine, and cluster headache) is still under discussion. Herein we report a patient suffering from hereditary hemochromatosis (homozygous C282Y mutation; OMIM: 235220, Locus 6p21.3) and daily headache fulfilling the IHSD-2 criteria of chronic migraine. Three treatments by venesection improved the headache substantially in frequency, intensity, and duration of attacks. We suggest treatment by venesection for iron depletion in patients suffering from hemochromatois and headache.