From the Thomas Jefferson University, Philadelphia, PA, USA (Dr. Silberstein); Mayo Clinic, Scottsdale, AZ, USA (Dr. Dodick); Diamond Headache Center, Chicago, IL, USA (Dr. Freitag); Savannah, GA, USA (Dr. Pearlman); Albert Einstein School of Medicine, Bronx, NY, USA (Drs. Hahn and Lipton); and Uniformed Services University, Bethesda, MD, USA (Dr. Scher).
Pharmacological Approaches to Managing Migraine and Associated Comorbidities—Clinical Considerations for Monotherapy Versus Polytherapy
Article first published online: 13 APR 2007
Headache: The Journal of Head and Face Pain
Volume 47, Issue 4, pages 585–599, April 2007
How to Cite
Silberstein, S. D., Dodick, D., Freitag, F., Pearlman, S. H., Hahn, S. R., Scher, A. I. and Lipton, R. B. (2007), Pharmacological Approaches to Managing Migraine and Associated Comorbidities—Clinical Considerations for Monotherapy Versus Polytherapy. Headache: The Journal of Head and Face Pain, 47: 585–599. doi: 10.1111/j.1526-4610.2007.00760.x
- Issue published online: 13 APR 2007
- Article first published online: 13 APR 2007
- Accepted for publication December 18, 2006.
Comorbidity is defined as an illness that occurs more frequently in association with a specific disorder than would be found as a coincidental association in the general population. Conditions that are frequently comorbid with migraine include depression, anxiety, stroke, epilepsy, sleep disorders, and other pain disorders. In addition, many common illnesses occur concomitantly (at the same time) with migraine and influence the treatment choice. Migraine management, and especially migraine prevention, can be challenging when patients have comorbid or concomitant illnesses. The objectives of this initiative are to review the literature on managing patients who have migraine and common comorbidities, present additional clinical approaches for care of these difficult patients, and evaluate the areas in which research is needed to establish evidence-based guidelines for the management of migraine with associated comorbid conditions.