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Relief From Migraine Headache With Aripiprazole Treatment

Authors

  • Lauren D. LaPorta MD, DFAPA


  • From the Department of Psychiatry, St. Joseph's Regional Medical Center, Paterson, NJ.

Address all correspondence to Dr. Lauren D. LaPorta, Department of Psychiatry, St. Joseph's Regional Medical Center, 703 Main St., Paterson, NJ 07503.

Abstract

There have been many reports of the association between migraine headaches and psychiatric disorders as well as of the utility of dopamine antagonists in the treatment of migraine headache. There is increasing evidence to support the activation of dopaminergic systems as a primary component of migraine pathogenesis. This report documents 3 cases of female migraineurs who received the dopamine modulator aripiprazole for treatment of co-occurring psychiatric disorders and experienced a decrease in migraine frequency and severity. A hypothesis as to the mechanism of action of dopamine regulation in migraine treatment is discussed.

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