Effects of Distraction Versus Spatial Discrimination on Laser-Evoked Potentials in Migraine
Article first published online: 7 JUN 2007
© 2008 the Authors
Headache: The Journal of Head and Face Pain
Volume 48, Issue 3, pages 408–416, March 2008
How to Cite
de Tommaso, M., Baumgartner, U., Sardaro, M., Difruscolo, O., Serpino, C. and Treede, R.-D. (2008), Effects of Distraction Versus Spatial Discrimination on Laser-Evoked Potentials in Migraine. Headache: The Journal of Head and Face Pain, 48: 408–416. doi: 10.1111/j.1526-4610.2007.00857.x
- Issue published online: 11 DEC 2007
- Article first published online: 7 JUN 2007
- Accepted for publication April 18, 2007.
- laser-evoked potentials;
Objectives.— To evaluate whether migraine patients exhibit less inhibition to painful stimuli when distracted from pain as compared to healthy subjects, testing the spatial discrimination of painful stimuli, the performance during the mental arithmetic task used to contrast the discrimination performance and the behavior of N1 and N2-P2 laser-evoked potentials (LEPs) amplitudes during spatial discrimination and during distraction.
Methods.— Eight migraine patients and 8 healthy controls were examined. During repetitive series of painful laser stimulation of the hand, they had to (1) perform a spatial discrimination task, contrasted by (2) a mental arithmetic task that served as distraction.
Results.— Patients made 50% to 100% more mistakes than controls in the spatial discrimination task (P < .001) as well as during mental arithmetic (P < .05). Whereas healthy subjects showed a marked decrease of the LEP vertex potential amplitudes during distraction compared to the discrimination task, no such attenuation of LEPs was seen in migraine patients (group × task interaction, P < .05). N1 amplitude exhibited a left-hemisphere dominance in both groups, significantly smaller amplitude in migraine patients, but no significant task modulation.
Conclusion.— Migraine patients exhibited reduced inhibition by attentional modulation of pain processing, accompanied by impaired spatial discrimination of painful stimuli.