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Familial Hemiplegic Migraine: Permanent Attack-Related Neurologic Deficits


  • David Dodick MD,

  • Michael Roarke MD

  • From the Mayo Clinic, Scottsdale—Neurology, Scottsdale, AZ.

Address all correspondence to David Dodick, MD, Mayo Clinic, Scottsdale—Neurology, Department of Neurology 13400 East Shea Blvd., Scottsdale, AZ 85259.


Hemiplegic migraine (HM) is characterized by motor weakness and at least one other aura symptom or sign that is fully reversible within 24 hours. While prolonged neurological impairment lasting weeks has been observed, persistent attack-related neurological deficits have not been described. This case illustrates the potential for permanent neurological deficits to occur as a sequelae of HM in the absence of infarction, and highlights potentially important pathophysiological and treatment implications.