From the Department of Medical and Surgical Pediatrics, Unit of Infantile Neuropsychiatry, University Hospital of Messina, Messina, Italy (Drs. Di Rosa, Attinà, Spanò, Ingegneri, Sgrò, Pustorino, Bonsignore, and Tortorella); Unit of Hematology, “Melacrino-Morelli” Hospital of Reggio Calabria, Reggio Calabria, Italy (Dr. Trapani-Lombardo).
Efficacy of Folic Acid in Children With Migraine, Hyperhomocysteinemia and MTHFR Polymorphisms
Article first published online: 9 OCT 2007
Headache: The Journal of Head and Face Pain
Volume 47, Issue 9, pages 1342–1344, October 2007
How to Cite
Di Rosa, G., Attinà, S., Spanò, M., Ingegneri, G., Sgrò, D. L., Pustorino, G., Bonsignore, M., Trapani-Lombardo, V. and Tortorella, G. (2007), Efficacy of Folic Acid in Children With Migraine, Hyperhomocysteinemia and MTHFR Polymorphisms. Headache: The Journal of Head and Face Pain, 47: 1342–1344. doi: 10.1111/j.1526-4610.2007.00932.x
Conflict of Interest: None
- Issue published online: 9 OCT 2007
- Article first published online: 9 OCT 2007
- Accepted for publication April 4, 2007.
- folic acid;
MTHFR gene variants C677T and A1298C seem to be related to an increased risk of migraine. Folates' metabolism could play a role in the pathophysiology of migraine. We supplemented 16 children with migraine, hyperhomocysteinemia, and MTHFR polymorphisms with folic acid and obtained a resolution/reduction of migraine attacks. Although the mechanism leading to these effects has been not made clear, we believe that the use of folic acid needs further investigations in migraineurs with hyperhomocysteinemia and MTHFR variants. A randomized, double-blind, placebo controlled crossover trial is needed to support these findings.