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Migraine and the Risk of Stroke, TIA, or Death in the UK (CME)
Article first published online: 3 DEC 2007
Headache: The Journal of Head and Face Pain
Volume 47, Issue 10, pages 1374–1384, November/December 2007
How to Cite
Becker, C., Brobert, G. P., Almqvist, P. M., Johansson, S., Jick, S. S. and Meier, C. R. (2007), Migraine and the Risk of Stroke, TIA, or Death in the UK (CME). Headache: The Journal of Head and Face Pain, 47: 1374–1384. doi: 10.1111/j.1526-4610.2007.00937.x
Conflict of Interest: None
- Issue published online: 3 DEC 2007
- Article first published online: 3 DEC 2007
- Accepted for publication July 7, 2007.
- General Practice Research Database;
Background.— Previous observational studies have reported a higher risk of stroke in migraine patients.
Objective.— We aimed to estimate the risk of stroke, transient ischemic attack (TIA), or death in migraineurs in the UK.
Method.— We conducted a population-based follow-up study within the General Practice Research Database from 1994 to 2001.
Results.— The relative risk (RR) of stroke in migraineurs compared with non-migraineurs was 2.2 (95% confidence interval [CI] 1.7-2.9). It was highest for patients with a migraine diagnosis recorded within 30 days prior to a stroke (odds ratio 11.1, 95% CI 5.69-21.5). The RR of TIA in migraineurs compared with non-migraineurs was 2.4 (95% CI 1.8-3.3), the mortality of migraineurs was slightly decreased.
Conclusion.— In our study, the RR of developing a stroke or a TIA was doubled in migraineurs as compared with non-migraineurs, while that for death was close to unity.