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Diffusion MRI During Migraine With Aura Attack Associated With Diagnostic Microbubbles Injection in Subjects With Large PFO


  • Conflict of Interest: None

Dr. Massimo Del Sette, Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Via De Toni 5, 16132 Genova, Italy.


The relationship between migraine with aura and patent foramen ovale (PFO) is still debatable. We report 2 cases of migraine with aura attacks after diagnostic microbubble injection for contrast transcranial Doppler (cTCD), in subjects with large PFO. In one case MR images, including diffusion weighted imaging and apparent diffusion coefficient, performed during aura did not show any signal abnormality. Patients with migraine with aura may have an attack during cTCD, probably by a “non-ischemic” mechanism.