Risk Factors for Headache Chronification

Authors

  • Ann I. Scher PhD,

    1. From the Uniformed Services University – Preventive Medicine Biometrics, Bethesda, MD, USA (Scher, Midgette); Albert Einstein College of Medicine – Neurology, Bronx, NY, USA (Lipton).
    Search for more papers by this author
  • Lynn A. Midgette MPH,

    1. From the Uniformed Services University – Preventive Medicine Biometrics, Bethesda, MD, USA (Scher, Midgette); Albert Einstein College of Medicine – Neurology, Bronx, NY, USA (Lipton).
    Search for more papers by this author
  • Richard B. Lipton MD

    1. From the Uniformed Services University – Preventive Medicine Biometrics, Bethesda, MD, USA (Scher, Midgette); Albert Einstein College of Medicine – Neurology, Bronx, NY, USA (Lipton).
    Search for more papers by this author

  • Conflict of Interest: None

Ann Scher, Preventive Medicine Biometrics, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.

Abstract

About 4% of the adult population and about 1% to 2% of children experience chronic attacks on a daily or near daily basis. While there is uncertainty about the biological mechanisms that lead to headache “chronification,” the epidemiologic literature has provided some insight into modifiable and nonmodifiable factors that appear to influence risk of headache progression. This review summarizes the evidence from population-based studies related to the chronic daily headache phenotype, natural history, and risk factors that may influence incidence, prevalence, or prognosis.

Ancillary