Triptans: Actions and Reactions


  • Conflict of Interest: None

S. Nahas, Thomas Jefferson University Hospital—Neurology, 111 S. 11th St. Suite 8130, Philadelphia, PA 19107-5092, USA.


Subcutaneous sumatriptan is superior to placebo in achieving headache relief. Some commonly reported adverse events are paresthesias, tingling, and transient worsening of headache. Why do patients develop these symptoms? Our unique case may shed light on its actions.