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Hemicrania Continua Evolving From Cluster Headache Responsive to Valproic Acid


  • Conflict of Interest: None

G. Lambru, Headache Centre, Department of Neurology, University of Parma, c/o Ospedale Maggiore, via Gramsci 14, 43100 Parma, Italy.


Hemicrania continua (HC) is a rare type of primary headache characterized by a prompt and enduring response to indomethacin. We describe a patient who suffered from cluster headache evolving into ipsilateral HC, who does not tolerate a long-term indomethacin therapy. The case was complex in terms of diagnosis, associated comorbidity, and choice of treatment; after several trials with different therapeutic regimens, we started the patient on a therapy with valproic acid and obtained an improvement of her HC.