Conflict of Interest: None
Nitroglycerin Headache and Nitroglycerin-Induced Primary Headaches From 1846 and Onwards: A Historical Overview and an Update
Article first published online: 25 FEB 2009
© 2009 the Authors. Journal compilation © 2009 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 49, Issue 3, pages 445–456, March 2009
How to Cite
Tfelt-Hansen, P. C. and Tfelt-Hansen, J. (2009), Nitroglycerin Headache and Nitroglycerin-Induced Primary Headaches From 1846 and Onwards: A Historical Overview and an Update. Headache: The Journal of Head and Face Pain, 49: 445–456. doi: 10.1111/j.1526-4610.2009.01342.x
- Issue published online: 25 FEB 2009
- Article first published online: 25 FEB 2009
- Accepted for publication September 22, 2008.
- nitroglycerin headache;
Nitroglycerin (NTG) (glyceryl trinitrate) was synthesized by the Italian chemist Ascanio Sobrero in Paris in 1846. A very unstable explosive, Alfred Nobel while working on explosives, combined it with Kiselguhr and patented it as dynamite in 1867. NTG was introduced in 1879 in medicine in the treatment of angina pectoris by the English doctor William Murrell. NTG-induced headache was quickly recognized as an important adverse event both in the industrial use of NTG, where it was used to produce dynamite, as well as in the use of NTG as drug. This review traces the evolution of our understanding of NTG headache.