Conflict of Interest: None
Cluster Attacks Responsive to Recreational Cannabis and Dronabinol
Article first published online: 11 FEB 2009
© 2009 the Authors. Journal compilation © 2009 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 49, Issue 6, pages 914–916, June 2009
How to Cite
Robbins, M. S., Tarshish, S., Solomon, S. and Grosberg, B. M. (2009), Cluster Attacks Responsive to Recreational Cannabis and Dronabinol. Headache: The Journal of Head and Face Pain, 49: 914–916. doi: 10.1111/j.1526-4610.2009.01344.x
- Issue published online: 27 MAY 2009
- Article first published online: 11 FEB 2009
- Accepted for publication November 10, 2008.
- cluster headache;
Pharmacological preparations of cannabinoid compounds have a variety of therapeutic uses in medicine, including different pain syndromes, but have not been previously reported as beneficial for cluster headache. We present a patient with cluster headache who was refractory to multiple acute and preventive medications but successfully aborted his attacks with recreational marijuana use; subsequent use of dronabinol provided equally effective pain relief. The beneficial effect may be related to the high concentration of cannabinoid receptors in the hypothalamus, which has been implicated as a site of dysfunction in neuroimaging studies of patients with cluster headache.