Acupuncture for Treating Acute Attacks of Migraine: A Randomized Controlled Trial

Authors

  • Ying Li MD, PhD,

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Fanrong Liang MD,

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Xuguang Yang MD,

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Xiaoping Tian MD,

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Jie Yan MD,

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Guojie Sun MD,

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Xiaorong Chang MD, PhD,

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Yong Tang MD, PhD,

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Tingting Ma MD,

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Li Zhou MD,

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Lei Lan BS,

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Wen Yao BS,

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Ran Zou MD

    1. From the Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China (Y. Li, F.R. Liang, X.G. Yang, X.P. Tian, Y. Tang, and T.T. Ma); Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China (J. Yan, X.R. Chang, L. Lan, and W. Yao); Hubei College of Traditional Chinese Medicine, Wuhan, Hubei, China (G.J. Sun, L. Zhou, and R. Zou).
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  • Financial support: This clinical trial was financially supported by the National Key Basic Research Program (973 Program) of China (Grant No. 2006CB504501).

  • Conflict of Interest: None

Y. Li and F.R. Liang, No. 37 Shi-er-qiao Road, Chengdu, Sichuan, China, 610075.

Abstract

Objective.— To discuss the results of a multicenter randomized controlled trial of the efficacy of verum acupuncture in treating acute migraine attacks.

Background.— Acupuncture has been used in China for centuries to treat migraine headache. Convincing evidence of its efficacy in alleviating pain, however, has been inadequate to date.

Methods.— A total of 218 patients with migraine were recruited for the study; 180 met the inclusion criteria; 175 completed the callback process and were randomized into 3 groups. One group received verum acupuncture while subjects in the other 2 groups were treated with sham acupuncture. Each patient received 1 session of treatment and was observed over a period of 24 hours. The main outcome measure was the differences in visual analog scale (VAS) scores before treatment and 0.5, 1, 2, and 4 hours after treatment.

Results.— Significant decreases in VAS scores from baseline were observed in the fourth hour after treatment when VAS was measured in the patients who received either verum acupuncture or sham acupunctures (P < .05). The VAS scores in the fourth hour after treatment decreased by a median of 1.0 cm, 0.5 cm, and 0.1 cm in the verum acupuncture group, sham acupuncture group 1, and sham acupuncture group 2, respectively. Similarly, there was a significant difference in the change in VAS scores from baseline in the second hour after treatment among the 3 groups (P = .006). Moreover, at the second hour after treatment, only patients treated with verum acupuncture showed significant decreases in VAS scores from baseline by a median of 0.7 cm (P < .001). Significant differences were observed in pain relief, relapse, or aggravation within 24 hours after treatment as well as in the general evaluations among the 3 groups (P < .05). Most patients in the acupuncture group experienced complete pain relief (40.7%) and did not experience recurrence or intensification of pain (79.6%).

Conclusion.— Verum acupuncture treatment is more effective than sham acupuncture based on either Chinese or Western nonacupoints in reducing the discomfort of acute migraine. Verum acupuncture is also clearly effective in relieving pain and preventing migraine relapse or aggravation. These findings support the contention that there are specific physiological effects that distinguish genuine acupoints from nonacupoints.

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