Correlations of Headache Diary Parameters, Quality of Life and Disability Scales

Authors

  • Andrea Hoppe MD,

    1. From the Center for Complementary Medicine Research, Department of Internal Medicine II, Technische Universität München, Munich, Germany (A. Hoppe, W. Weidenhammer, D. Melchart, and K. Linde); Institute of Medical Statistics and Epidemiology, Technische Universität München, Munich, Germany (S. Wagenpfeil); Graduate School of Information Science in Health (GSISH), Technische Universität München, Munich, Germany (S. Wagenpfeil); Institut für Naturheilkunde, Department für Innere Medizin, Universitätsspital Zürich, Switzerland (D. Melchart).
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  • Wolfgang Weidenhammer PhD,

    1. From the Center for Complementary Medicine Research, Department of Internal Medicine II, Technische Universität München, Munich, Germany (A. Hoppe, W. Weidenhammer, D. Melchart, and K. Linde); Institute of Medical Statistics and Epidemiology, Technische Universität München, Munich, Germany (S. Wagenpfeil); Graduate School of Information Science in Health (GSISH), Technische Universität München, Munich, Germany (S. Wagenpfeil); Institut für Naturheilkunde, Department für Innere Medizin, Universitätsspital Zürich, Switzerland (D. Melchart).
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  • Stefan Wagenpfeil PhD,

    1. From the Center for Complementary Medicine Research, Department of Internal Medicine II, Technische Universität München, Munich, Germany (A. Hoppe, W. Weidenhammer, D. Melchart, and K. Linde); Institute of Medical Statistics and Epidemiology, Technische Universität München, Munich, Germany (S. Wagenpfeil); Graduate School of Information Science in Health (GSISH), Technische Universität München, Munich, Germany (S. Wagenpfeil); Institut für Naturheilkunde, Department für Innere Medizin, Universitätsspital Zürich, Switzerland (D. Melchart).
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  • Dieter Melchart MD,

    1. From the Center for Complementary Medicine Research, Department of Internal Medicine II, Technische Universität München, Munich, Germany (A. Hoppe, W. Weidenhammer, D. Melchart, and K. Linde); Institute of Medical Statistics and Epidemiology, Technische Universität München, Munich, Germany (S. Wagenpfeil); Graduate School of Information Science in Health (GSISH), Technische Universität München, Munich, Germany (S. Wagenpfeil); Institut für Naturheilkunde, Department für Innere Medizin, Universitätsspital Zürich, Switzerland (D. Melchart).
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  • Klaus Linde MD

    1. From the Center for Complementary Medicine Research, Department of Internal Medicine II, Technische Universität München, Munich, Germany (A. Hoppe, W. Weidenhammer, D. Melchart, and K. Linde); Institute of Medical Statistics and Epidemiology, Technische Universität München, Munich, Germany (S. Wagenpfeil); Graduate School of Information Science in Health (GSISH), Technische Universität München, Munich, Germany (S. Wagenpfeil); Institut für Naturheilkunde, Department für Innere Medizin, Universitätsspital Zürich, Switzerland (D. Melchart).
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  • Financial support: The trials on which the secondary analyses presented are based were funded by the following German social health insurance funds: Deutsche Angestellten-Krankenkasse (DAK); Barmer Ersatzkasse (BEK); Kaufmännische Krankenkasse (KKH); Hamburg-Münchener Krankenkasse (HaMü); Hanseatische Kranken kasse (HEK); Gmünder Ersatzkasse (GEK); HZK Kranken kasse für Bau- und Holzberufe; Brühler Ersatzkasse; Krankenkasse Eintracht Heusenstamm (KEH); Buchdrucker Krankenkasse (BK).

  • Conflict of interest: None

K. Linde, Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universität München, Kaiserstr. 9, 80801 Munich, Germany.

Abstract

Objective.— We aimed to investigate (1) to which extent headache diary variables correlate among each other; (2) to which extent they correlate with generic measures of quality of life and disability; (3) and whether correlations vary over time.

Methods.— We performed a secondary analysis of data from 301 patients suffering from migraine and 270 patients suffering from tension-type headache collected in 2 randomized trials of acupuncture. We calculated product–moment correlation coefficients.

Results.— Correlations between diary parameters varied to a great extent. Attack frequency, a measure recommended by the International Headache Society as a primary outcome measure for migraine prophylaxis trials, correlated only moderately with other diary outcomes. At baseline the parameters measured in the headache diary correlated only weakly with the generic outcome measures. After 12 weeks these correlations had increased considerably.

Conclusion.— Our findings suggest that participants in headache trials “learn” to fill in diaries and generic instruments in a more consistent manner during the course of the study.

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