A Critical View on the Role of Migraine Triggers in the Genesis of Migraine Pain
Article first published online: 27 MAY 2009
© 2009 the Authors. Journal compilation © 2009 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 49, Issue 6, pages 953–957, June 2009
How to Cite
Levy, D., Strassman, A. M. and Burstein, R. (2009), A Critical View on the Role of Migraine Triggers in the Genesis of Migraine Pain. Headache: The Journal of Head and Face Pain, 49: 953–957. doi: 10.1111/j.1526-4610.2009.01444.x
- Issue published online: 27 MAY 2009
- Article first published online: 27 MAY 2009
- Accepted for publication March 25, 2009.
- migraine triggers;
- meningeal nociceptors
A number of distinct endogenous and exogenous factors have been implicated in migraine precipitation but the exact nature of the triggering process itself and its relationship to the genesis of the headache remains largely speculative. In this article, we examine the potential sites and downstream cascades through which migraine triggers might exert their action to promote the activation of the migraine pain pathway. We further look at the laterality of the headache as a potential indicator for the site of migraine pain initiation and examine the question of triggering factor specificity in relation to the current understanding of migraine pathophysiology.