Single Nucleotide Polymorphisms of the Serotonin Transporter Gene in Migraine – An Association Study

Authors

  • Bettina Bayerer PhD,

    1. From Department of Neurology, University of Essen, Essen, Germany (B. Bayerer, I. Savidou, M. Küper, C.F. Schorn, A. Wissmann, H.C. Diener, and V. Limmroth); Paul-Ehrlich-Institute, Langen, Germany (J. Engelbergs); Institute for Medical Informatics, Biometry and Epidemiology, University of Essen, Essen, Germany (T. Boes); Institute for Transfusion Medicine at the University of Essen, Essen, Germany (D. Knop); Department of Neurology, Cologne City Hospitals, University of Cologne, Cologne, Germany (B. Bayerer and V. Limmroth).
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  • Jörg Engelbergs PhD,

    1. From Department of Neurology, University of Essen, Essen, Germany (B. Bayerer, I. Savidou, M. Küper, C.F. Schorn, A. Wissmann, H.C. Diener, and V. Limmroth); Paul-Ehrlich-Institute, Langen, Germany (J. Engelbergs); Institute for Medical Informatics, Biometry and Epidemiology, University of Essen, Essen, Germany (T. Boes); Institute for Transfusion Medicine at the University of Essen, Essen, Germany (D. Knop); Department of Neurology, Cologne City Hospitals, University of Cologne, Cologne, Germany (B. Bayerer and V. Limmroth).
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  • Irini Savidou MD,

    1. From Department of Neurology, University of Essen, Essen, Germany (B. Bayerer, I. Savidou, M. Küper, C.F. Schorn, A. Wissmann, H.C. Diener, and V. Limmroth); Paul-Ehrlich-Institute, Langen, Germany (J. Engelbergs); Institute for Medical Informatics, Biometry and Epidemiology, University of Essen, Essen, Germany (T. Boes); Institute for Transfusion Medicine at the University of Essen, Essen, Germany (D. Knop); Department of Neurology, Cologne City Hospitals, University of Cologne, Cologne, Germany (B. Bayerer and V. Limmroth).
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  • Tanja Boes PhD,

    1. From Department of Neurology, University of Essen, Essen, Germany (B. Bayerer, I. Savidou, M. Küper, C.F. Schorn, A. Wissmann, H.C. Diener, and V. Limmroth); Paul-Ehrlich-Institute, Langen, Germany (J. Engelbergs); Institute for Medical Informatics, Biometry and Epidemiology, University of Essen, Essen, Germany (T. Boes); Institute for Transfusion Medicine at the University of Essen, Essen, Germany (D. Knop); Department of Neurology, Cologne City Hospitals, University of Cologne, Cologne, Germany (B. Bayerer and V. Limmroth).
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  • Michael Küper MD,

    1. From Department of Neurology, University of Essen, Essen, Germany (B. Bayerer, I. Savidou, M. Küper, C.F. Schorn, A. Wissmann, H.C. Diener, and V. Limmroth); Paul-Ehrlich-Institute, Langen, Germany (J. Engelbergs); Institute for Medical Informatics, Biometry and Epidemiology, University of Essen, Essen, Germany (T. Boes); Institute for Transfusion Medicine at the University of Essen, Essen, Germany (D. Knop); Department of Neurology, Cologne City Hospitals, University of Cologne, Cologne, Germany (B. Bayerer and V. Limmroth).
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  • Christoph F. Schorn MD,

    1. From Department of Neurology, University of Essen, Essen, Germany (B. Bayerer, I. Savidou, M. Küper, C.F. Schorn, A. Wissmann, H.C. Diener, and V. Limmroth); Paul-Ehrlich-Institute, Langen, Germany (J. Engelbergs); Institute for Medical Informatics, Biometry and Epidemiology, University of Essen, Essen, Germany (T. Boes); Institute for Transfusion Medicine at the University of Essen, Essen, Germany (D. Knop); Department of Neurology, Cologne City Hospitals, University of Cologne, Cologne, Germany (B. Bayerer and V. Limmroth).
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  • Andreas Wissmann VMD,

    1. From Department of Neurology, University of Essen, Essen, Germany (B. Bayerer, I. Savidou, M. Küper, C.F. Schorn, A. Wissmann, H.C. Diener, and V. Limmroth); Paul-Ehrlich-Institute, Langen, Germany (J. Engelbergs); Institute for Medical Informatics, Biometry and Epidemiology, University of Essen, Essen, Germany (T. Boes); Institute for Transfusion Medicine at the University of Essen, Essen, Germany (D. Knop); Department of Neurology, Cologne City Hospitals, University of Cologne, Cologne, Germany (B. Bayerer and V. Limmroth).
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  • Dietmar Knop MD,

    1. From Department of Neurology, University of Essen, Essen, Germany (B. Bayerer, I. Savidou, M. Küper, C.F. Schorn, A. Wissmann, H.C. Diener, and V. Limmroth); Paul-Ehrlich-Institute, Langen, Germany (J. Engelbergs); Institute for Medical Informatics, Biometry and Epidemiology, University of Essen, Essen, Germany (T. Boes); Institute for Transfusion Medicine at the University of Essen, Essen, Germany (D. Knop); Department of Neurology, Cologne City Hospitals, University of Cologne, Cologne, Germany (B. Bayerer and V. Limmroth).
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  • Hans C. Diener MD,

    1. From Department of Neurology, University of Essen, Essen, Germany (B. Bayerer, I. Savidou, M. Küper, C.F. Schorn, A. Wissmann, H.C. Diener, and V. Limmroth); Paul-Ehrlich-Institute, Langen, Germany (J. Engelbergs); Institute for Medical Informatics, Biometry and Epidemiology, University of Essen, Essen, Germany (T. Boes); Institute for Transfusion Medicine at the University of Essen, Essen, Germany (D. Knop); Department of Neurology, Cologne City Hospitals, University of Cologne, Cologne, Germany (B. Bayerer and V. Limmroth).
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  • Volker Limmroth MD

    1. From Department of Neurology, University of Essen, Essen, Germany (B. Bayerer, I. Savidou, M. Küper, C.F. Schorn, A. Wissmann, H.C. Diener, and V. Limmroth); Paul-Ehrlich-Institute, Langen, Germany (J. Engelbergs); Institute for Medical Informatics, Biometry and Epidemiology, University of Essen, Essen, Germany (T. Boes); Institute for Transfusion Medicine at the University of Essen, Essen, Germany (D. Knop); Department of Neurology, Cologne City Hospitals, University of Cologne, Cologne, Germany (B. Bayerer and V. Limmroth).
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  • Conflict of Interest: None

Bettina Bayerer, Department of Neurology, Cologne City Hospitals, Ostmerheimer Str. 200, 51109 Cologne, Germany.

Abstract

We report a case–control study with 251 unrelated migraine patients and 192 unrelated healthy controls to evaluate an association between the polymorphisms of the 5-HT transporter (5-HTT) gene rs2066713 and rs1979572 and different migraine phenotypes. We found a genetic association for the A allele of rs1979572 for migraine with aura (MA) especially in women as well as a significant lower prevalence for MA for carrier of the A allele of rs2066713 in women.

These findings support previous results suggesting that the 5-HTT gene is involved in the polygenic etiology of MA. These data further suggest that women are more likely to be clinically affected by mutations in the 5-HTT gene than men.

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