Conflict of Interest: None
Partially Reversible Cortical Metabolic Dysfunction in Familial Hemiplegic Migraine With Prolonged Aura
Article first published online: 5 MAR 2010
© 2010 the Authors. Journal compilation © 2010 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 50, Issue 5, pages 872–877, May 2010
How to Cite
Guedj, E., Belenotti, P., Serratrice, J., Ene, N., Pineau, S., Donnet, A., Mundler, O. and Weiller, P.-J. (2010), Partially Reversible Cortical Metabolic Dysfunction in Familial Hemiplegic Migraine With Prolonged Aura. Headache: The Journal of Head and Face Pain, 50: 872–877. doi: 10.1111/j.1526-4610.2010.01634.x
- Issue published online: 23 APR 2010
- Article first published online: 5 MAR 2010
- Accepted for publication January 14, 2010.
- familial hemiplegic migraine;
- cerebral blood flow
We report a SPECT and PET voxel-based analysis of cerebral blood flow and metabolic rate for glucose in a 23-year-old woman with familial hemiplegic migraine (FHM) caused by ATP1A2 gene mutation. In comparison with healthy subjects, a PET scan showed brain glucose hypometabolism, controlaterally to the hemiplegia, in the perisylvian area early in the attack (Day 1), without any SPECT perfusion abnormalities. Decrease in metabolic rate was only partially reversible at Day 78, concordant at this time with a remaining hemisensory loss. These findings provide further evidence for a primary cortical metabolic dysfunction in FHM.