Reversible Hypohidrosis With Topiramate Therapy for Chronic Migraine

Authors

  • Shira Y. Markowitz MD,

    1. From the Albert Einstein College of Medicine, Saul R. Korey Department of Neurology, Montefiore Headache Center, Bronx, NY, USA (S.Y. Markowitz, M.S. Robbins, and B.M. Grosberg); Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA (C. Cascella and H.U. Sheikh).
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  • Matthew S. Robbins MD,

    1. From the Albert Einstein College of Medicine, Saul R. Korey Department of Neurology, Montefiore Headache Center, Bronx, NY, USA (S.Y. Markowitz, M.S. Robbins, and B.M. Grosberg); Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA (C. Cascella and H.U. Sheikh).
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  • Clair Cascella MD,

    1. From the Albert Einstein College of Medicine, Saul R. Korey Department of Neurology, Montefiore Headache Center, Bronx, NY, USA (S.Y. Markowitz, M.S. Robbins, and B.M. Grosberg); Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA (C. Cascella and H.U. Sheikh).
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  • Huma U. Sheikh MD,

    1. From the Albert Einstein College of Medicine, Saul R. Korey Department of Neurology, Montefiore Headache Center, Bronx, NY, USA (S.Y. Markowitz, M.S. Robbins, and B.M. Grosberg); Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA (C. Cascella and H.U. Sheikh).
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  • Brian M. Grosberg MD

    1. From the Albert Einstein College of Medicine, Saul R. Korey Department of Neurology, Montefiore Headache Center, Bronx, NY, USA (S.Y. Markowitz, M.S. Robbins, and B.M. Grosberg); Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA (C. Cascella and H.U. Sheikh).
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  • Conflicts of Interest: None

S. Markowitz, Neurology/Headache, Montefiore Medical Center, 1575 Blondell Avenue, Bronx, NY 10461, USA.

Abstract

Topiramate is an anticonvulsant medication that is widely used for migraine prophylaxis. Hypohidrosis and hyperthermia are 2 rare adverse effects of topiramate treatment, which have mainly occurred in pediatric epilepsy patients. Herein, we describe the first case of reversible hypohidrosis in an adult patient treated with topiramate for chronic migraine.

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