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Headache in Thrombotic Thrombocytopenic Purpura: Two Cases With Pathophysiological Considerations

Authors

  • David Bezov MD,

    1. From the Montefiore Medical Center—Neurology, Albert Einstein College of Medicine, Bronx, NY, USA (D. Bezov, R. Lipton, C.G. Zhao, and S. Ashina); Yale-New Haven Hospital—Medicine, Yale University School of Medicine, New Haven, CT, USA (N. Podoltsev).
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  • Richard B. Lipton MD,

    1. From the Montefiore Medical Center—Neurology, Albert Einstein College of Medicine, Bronx, NY, USA (D. Bezov, R. Lipton, C.G. Zhao, and S. Ashina); Yale-New Haven Hospital—Medicine, Yale University School of Medicine, New Haven, CT, USA (N. Podoltsev).
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  • Nikolai Podoltsev MD, PhD,

    1. From the Montefiore Medical Center—Neurology, Albert Einstein College of Medicine, Bronx, NY, USA (D. Bezov, R. Lipton, C.G. Zhao, and S. Ashina); Yale-New Haven Hospital—Medicine, Yale University School of Medicine, New Haven, CT, USA (N. Podoltsev).
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  • Chi G. Zhao MD,

    1. From the Montefiore Medical Center—Neurology, Albert Einstein College of Medicine, Bronx, NY, USA (D. Bezov, R. Lipton, C.G. Zhao, and S. Ashina); Yale-New Haven Hospital—Medicine, Yale University School of Medicine, New Haven, CT, USA (N. Podoltsev).
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  • Sait Ashina MD

    1. From the Montefiore Medical Center—Neurology, Albert Einstein College of Medicine, Bronx, NY, USA (D. Bezov, R. Lipton, C.G. Zhao, and S. Ashina); Yale-New Haven Hospital—Medicine, Yale University School of Medicine, New Haven, CT, USA (N. Podoltsev).
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  • Conflict of Interest: None

D. Bezov, Montefiore Medical Center—Neurology, 3351 Steuben Avenue Bronx, NY 10467, USA. E-mail:skiff229@yahoo.com.

Abstract

Headache is one of the most common neurological symptoms reported by patients with thrombotic thrombocytopenic purpura (TTP). Reports of headache characteristics in patients with TTP are rare. We report 2 cases of headache in a setting of TTP and review previous reports. Headache in TTP can have features in common with both migraine and tension-type headache. Although the pathophysiology of headache in TTP is not certain, platelet aggregation and activation may play a key role.

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