Conflict of Interest: None
A Remarkable Increase in Total Homocysteine Concentrations in the CSF of Migraine Patients With Aura
Article first published online: 3 NOV 2010
© 2010 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 50, Issue 10, pages 1561–1569, November/December 2010
How to Cite
Isobe, C. and Terayama, Y. (2010), A Remarkable Increase in Total Homocysteine Concentrations in the CSF of Migraine Patients With Aura. Headache: The Journal of Head and Face Pain, 50: 1561–1569. doi: 10.1111/j.1526-4610.2010.01713.x
- Issue published online: 3 NOV 2010
- Article first published online: 3 NOV 2010
- Accepted for publication April 21, 2010.
- migraine with aura;
- migraine without aura;
- free homocysteine;
- total homocysteine;
- cardiocerebrovascular conditions;
- cerebrospinal fluid
Objective.— To investigate whether total and free homocysteine (HC) levels are increased in the cerebrospinal fluid (CSF) of patients with migraine headache compared with normal control populations.
Methods.— The concentrations of free and total HC in the CSF of migraine without aura (MOA) and migraine with aura (MWA) patients were determined.
Results.— The concentration of free HC did not differ significantly from normal controls, but the total HC concentration was significantly higher in MOA and MWA patients (41% increase in MOA, P < .001 and 376% increase in MWA, P < .0001) in the mean of the confidence interval of each groups compared with normal controls).
Conclusions.— These findings suggest that an increase of total HC concentration in the brain is commonly seen in migraine patient and is particularly pronounced in MWA sufferers. We speculate that total HC not only contribute to the development of atherosclerotic conditions, including cardiocerebrovascular diseases, but also reflects an epiphenomenon.