Conflict of Interest: None
Sleep and Headache: The Biological Basis
Article first published online: 13 JUL 2010
© 2010 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 50, Issue 7, pages 1246–1251, July/August 2010
How to Cite
Evers, S. (2010), Sleep and Headache: The Biological Basis. Headache: The Journal of Head and Face Pain, 50: 1246–1251. doi: 10.1111/j.1526-4610.2010.01730.x
- Issue published online: 13 JUL 2010
- Article first published online: 13 JUL 2010
- Accepted for publication March 18, 2010.
- cluster headache;
- hypnic headache;
Sleep and trigeminal pain processing share several common pathways with respect to neurotransmission and functions of distinct brain areas. In this review, the role of the most important brain stem and midbrain regions for this link is discussed. The central structure involved in both headache and sleep is the hypothalamus in which the orexinergic neurons originate. These neurons project to the periaqueductal grey and are probably the anatomic and physiological link between headache and sleep. Another relevant system for this interrelationship is the melatonin metabolism. However, basic research in this field is still very preliminary and a holistic hypothesis on how sleep physiology impacts headache and vice versa is still missing.