Conflict of Interest: None
Prolonged Sporadic Hemiplegic Migraine Associated With a Novel De Novo Missense ATP1A2 Gene Mutation
Article first published online: 4 NOV 2010
© 2010 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 51, Issue 3, pages 447–450, March 2011
How to Cite
De Sanctis, S., Grieco, G. S., Breda, L., Casali, C., Nozzi, M., Del Torto, M., Chiarelli, F. and Verrotti, A. (2011), Prolonged Sporadic Hemiplegic Migraine Associated With a Novel De Novo Missense ATP1A2 Gene Mutation. Headache: The Journal of Head and Face Pain, 51: 447–450. doi: 10.1111/j.1526-4610.2010.01793.x
- Issue published online: 25 FEB 2011
- Article first published online: 4 NOV 2010
- Accepted for publication September 10, 2010.
- sporadic hemiplegic migraine;
- missense mutation;
- prolonged aura
Hemiplegic migraine is a rare form of migraine characterized by periodic attacks of migraine with neurologic aura and transient hemiplegia. There are familial and sporadic cases, both on a genetic basis; we describe the case of a 6-year-old boy affected by sporadic hemiplegic migraine, showing a novel ATP1A2 gene missense mutation (p.Gly715Arg) in exon 16. Long-term treatment with flunarizine resulted in good clinical response and prevention of further attacks.