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Prolonged Sporadic Hemiplegic Migraine Associated With a Novel De Novo Missense ATP1A2 Gene Mutation

Authors

  • Sara De Sanctis MD,

    1. From the Department of Pediatrics, University of Chieti, Chieti, Italy (S. De Sanctis, L. Breda, M. Nozzi, M. Del Torto, F. Chiarelli, and A. Verrotti); Laboratory of Neurogenetics, IRCCS National Neurological Institute “C. Mondino,” Pavia, Italy (G.S. Grieco); Department of Neurology and ORL, Sapienza University of Rome-Polo Pontino, Latina, Italy (C. Casali).
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  • Gaetano Salvatore Grieco PhD,

    1. From the Department of Pediatrics, University of Chieti, Chieti, Italy (S. De Sanctis, L. Breda, M. Nozzi, M. Del Torto, F. Chiarelli, and A. Verrotti); Laboratory of Neurogenetics, IRCCS National Neurological Institute “C. Mondino,” Pavia, Italy (G.S. Grieco); Department of Neurology and ORL, Sapienza University of Rome-Polo Pontino, Latina, Italy (C. Casali).
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  • Luciana Breda MD,

    1. From the Department of Pediatrics, University of Chieti, Chieti, Italy (S. De Sanctis, L. Breda, M. Nozzi, M. Del Torto, F. Chiarelli, and A. Verrotti); Laboratory of Neurogenetics, IRCCS National Neurological Institute “C. Mondino,” Pavia, Italy (G.S. Grieco); Department of Neurology and ORL, Sapienza University of Rome-Polo Pontino, Latina, Italy (C. Casali).
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  • Carlo Casali MD,

    1. From the Department of Pediatrics, University of Chieti, Chieti, Italy (S. De Sanctis, L. Breda, M. Nozzi, M. Del Torto, F. Chiarelli, and A. Verrotti); Laboratory of Neurogenetics, IRCCS National Neurological Institute “C. Mondino,” Pavia, Italy (G.S. Grieco); Department of Neurology and ORL, Sapienza University of Rome-Polo Pontino, Latina, Italy (C. Casali).
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  • Manuela Nozzi MD,

    1. From the Department of Pediatrics, University of Chieti, Chieti, Italy (S. De Sanctis, L. Breda, M. Nozzi, M. Del Torto, F. Chiarelli, and A. Verrotti); Laboratory of Neurogenetics, IRCCS National Neurological Institute “C. Mondino,” Pavia, Italy (G.S. Grieco); Department of Neurology and ORL, Sapienza University of Rome-Polo Pontino, Latina, Italy (C. Casali).
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  • Marianna Del Torto MD,

    1. From the Department of Pediatrics, University of Chieti, Chieti, Italy (S. De Sanctis, L. Breda, M. Nozzi, M. Del Torto, F. Chiarelli, and A. Verrotti); Laboratory of Neurogenetics, IRCCS National Neurological Institute “C. Mondino,” Pavia, Italy (G.S. Grieco); Department of Neurology and ORL, Sapienza University of Rome-Polo Pontino, Latina, Italy (C. Casali).
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  • Francesco Chiarelli MD,

    1. From the Department of Pediatrics, University of Chieti, Chieti, Italy (S. De Sanctis, L. Breda, M. Nozzi, M. Del Torto, F. Chiarelli, and A. Verrotti); Laboratory of Neurogenetics, IRCCS National Neurological Institute “C. Mondino,” Pavia, Italy (G.S. Grieco); Department of Neurology and ORL, Sapienza University of Rome-Polo Pontino, Latina, Italy (C. Casali).
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  • Alberto Verrotti MD

    1. From the Department of Pediatrics, University of Chieti, Chieti, Italy (S. De Sanctis, L. Breda, M. Nozzi, M. Del Torto, F. Chiarelli, and A. Verrotti); Laboratory of Neurogenetics, IRCCS National Neurological Institute “C. Mondino,” Pavia, Italy (G.S. Grieco); Department of Neurology and ORL, Sapienza University of Rome-Polo Pontino, Latina, Italy (C. Casali).
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  • Conflict of Interest: None

S. De Sanctis, Department of Pediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, Italy.

Abstract

Hemiplegic migraine is a rare form of migraine characterized by periodic attacks of migraine with neurologic aura and transient hemiplegia. There are familial and sporadic cases, both on a genetic basis; we describe the case of a 6-year-old boy affected by sporadic hemiplegic migraine, showing a novel ATP1A2 gene missense mutation (p.Gly715Arg) in exon 16. Long-term treatment with flunarizine resulted in good clinical response and prevention of further attacks.

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