Conflict of Interest: No conflict.
Bronchial Hyper-Reactivity in Migraine Without Aura: Is It a New Clue for Inflammation?
Article first published online: 10 NOV 2010
© 2010 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 51, Issue 3, pages 426–431, March 2011
How to Cite
Kaleagasi, H., Özgür, E., Özge, C. and Özge, A. (2011), Bronchial Hyper-Reactivity in Migraine Without Aura: Is It a New Clue for Inflammation?. Headache: The Journal of Head and Face Pain, 51: 426–431. doi: 10.1111/j.1526-4610.2010.01798.x
Financial support: There is no source of financial support for this research.
- Issue published online: 25 FEB 2011
- Article first published online: 10 NOV 2010
- Accepted for publication September 19, 2010.
- migraine without aura;
- bronchial hyper-reactivity;
Objective.— We attempted to investigate the relationship between migraine without aura (MwoA) and bronchial hyper-reactivity to postulate inflammation as an underlying mechanism in migraine.
Background.— Comorbidity of migraine and atopic diseases such as asthma has been an argument for suspected immune system dysfunction in migraineurs.
Methods.— Twenty patients with MwoA and 5 control subjects without history of atophy and asthma were included in study. Subjects with abnormal physical examination and chest radiographs were excluded. After a normal spirometry, methacholine bronchoprovocation test was performed in all subjects and controls according to 5 breath dosimeter methods.
Results.— Sixteen of 20 patients and 2 of 5 control subjects were women. Mean ages were 37.5 (19-56) and 33.8 (26-43) years, respectively. Methacholine bronchoprovocation test was positive in 3 patients (15%) but was normal in all controls (0%).
Conclusions.— The relationship between MwoA and bronchial hyper-reactivity may help to postulate the inflammation in migraine as an underlying mechanism.