These authors contributed equally to this work.
Body Mass Index and Adult Weight Gain Among Reproductive Age Women With Migraine
Version of Record online: 26 JAN 2011
© 2011 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 51, Issue 4, pages 559–569, April 2011
How to Cite
Vo, M., Ainalem, A., Qiu, C., Peterlin, B. L., Aurora, S. K. and Williams, M. A. (2011), Body Mass Index and Adult Weight Gain Among Reproductive Age Women With Migraine. Headache: The Journal of Head and Face Pain, 51: 559–569. doi: 10.1111/j.1526-4610.2010.01833.x
Study funding: This research was supported by awards from the National Institutes of Health (R01 HD-032562, R01HD-055566, and T37-MD001449).
Conflict of Interest: None to declare.
- Issue online: 1 APR 2011
- Version of Record online: 26 JAN 2011
- Accepted for publication November 23, 2010.
- adult weight gain;
- pediatric migraine;
- body mass index
Objective.— To evaluate the cross-sectional relationship between migraine and pregravid obesity; and to assess the risk of adult weight gain among women with history of a pediatric diagnosis of migraine.
Background.— Obesity, comorbid with pain disorders including migraine, shares common pathophysiological characteristics including systemic inflammation, and derangements in adipose-tissue derived cytokines. Despite biochemical and epidemiological commonalities, obesity–migraine associations have been inconsistently observed.
Methods.— A cohort of 3733 women was interviewed during early pregnancy. We ascertained participants' self-reported history of physician-diagnosed migraine and collected self-reported information about pregravid weight, adult height, and net weight change from age 18 to the 3-months period before pregnancy. Using pregravid body mass index, we categorized participants as follows: lean (<18.5 kg/m2), normal (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2), obese (30-34.9 kg/m2), severely obese (35-39.9 kg/m2), and morbidly obese (≥40 kg/m2). Logistic regression procedures were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Results.— After adjusting for confounders, relative to normal weight women, obese women had a 1.48-fold increased odds of migraine (OR = 1.48; 95% CI 1.12-1.96). Severely obese (OR = 2.07; 95% CI 1.27-3.39) and morbidly obese (OR = 2.75; 95% CI 1.60-4.70) had the highest odds of migraines. Women with a history of diagnosed pediatric migraine had a 1.67-fold higher odds of gaining ≥10.0 kg above their weight at age 18, as compared with non-migraineurs (OR = 1.67; 95% CI 1.13-2.47).
Conclusion.— These data support earlier observations of migraine–obesity association among women, and extend the literature to include evidence of adult weight gain among women with a history of pediatric migraine.