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Body Mass Index and Adult Weight Gain Among Reproductive Age Women With Migraine

Authors

  • Michelle Vo,

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    • These authors contributed equally to this work.

  • Abinnet Ainalem,

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    • These authors contributed equally to this work.

  • Chunfang Qiu MD, MS,

    1. From the Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA (M. Vo, A. Ainalem, and M.A. Williams); Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA (C. Qiu and M.A. Williams); Johns Hopkins University, Bayview Medical Center, Baltimore, MD, USA (B.L. Peterlin); Swedish Headache Center, Seattle, WA, USA (S.K. Aurora).
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  • B. Lee Peterlin DO,

    1. From the Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA (M. Vo, A. Ainalem, and M.A. Williams); Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA (C. Qiu and M.A. Williams); Johns Hopkins University, Bayview Medical Center, Baltimore, MD, USA (B.L. Peterlin); Swedish Headache Center, Seattle, WA, USA (S.K. Aurora).
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  • Sheena K. Aurora MD,

    1. From the Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA (M. Vo, A. Ainalem, and M.A. Williams); Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA (C. Qiu and M.A. Williams); Johns Hopkins University, Bayview Medical Center, Baltimore, MD, USA (B.L. Peterlin); Swedish Headache Center, Seattle, WA, USA (S.K. Aurora).
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  • Michelle A. Williams ScD

    1. From the Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA (M. Vo, A. Ainalem, and M.A. Williams); Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA (C. Qiu and M.A. Williams); Johns Hopkins University, Bayview Medical Center, Baltimore, MD, USA (B.L. Peterlin); Swedish Headache Center, Seattle, WA, USA (S.K. Aurora).
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  • Study funding: This research was supported by awards from the National Institutes of Health (R01 HD-032562, R01HD-055566, and T37-MD001449).

  • Conflict of Interest: None to declare.

M.A. Williams, Department of Epidemiology, University of Washington School of Public Health, 1959 NE Pacific Street (Box 357236), Health Sciences Building F-161E, Seattle, WA 98195, USA.

Abstract

(Headache 2011;51:559-569)

Objective.— To evaluate the cross-sectional relationship between migraine and pregravid obesity; and to assess the risk of adult weight gain among women with history of a pediatric diagnosis of migraine.

Background.— Obesity, comorbid with pain disorders including migraine, shares common pathophysiological characteristics including systemic inflammation, and derangements in adipose-tissue derived cytokines. Despite biochemical and epidemiological commonalities, obesity–migraine associations have been inconsistently observed.

Methods.— A cohort of 3733 women was interviewed during early pregnancy. We ascertained participants' self-reported history of physician-diagnosed migraine and collected self-reported information about pregravid weight, adult height, and net weight change from age 18 to the 3-months period before pregnancy. Using pregravid body mass index, we categorized participants as follows: lean (<18.5 kg/m2), normal (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2), obese (30-34.9 kg/m2), severely obese (35-39.9 kg/m2), and morbidly obese (≥40 kg/m2). Logistic regression procedures were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).

Results.— After adjusting for confounders, relative to normal weight women, obese women had a 1.48-fold increased odds of migraine (OR = 1.48; 95% CI 1.12-1.96). Severely obese (OR = 2.07; 95% CI 1.27-3.39) and morbidly obese (OR = 2.75; 95% CI 1.60-4.70) had the highest odds of migraines. Women with a history of diagnosed pediatric migraine had a 1.67-fold higher odds of gaining ≥10.0 kg above their weight at age 18, as compared with non-migraineurs (OR = 1.67; 95% CI 1.13-2.47).

Conclusion.— These data support earlier observations of migraine–obesity association among women, and extend the literature to include evidence of adult weight gain among women with a history of pediatric migraine.

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