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Keywords:

  • new daily persistent headache;
  • chronic daily headache;
  • tumor necrosis factor alpha;
  • joint hypermobility

New daily persistent headache is a recognized form of primary chronic daily headache. It is unique in its presentation and course. The goal of this article is to discuss the clinical characteristics, triggering factors, possible underlying pathogenesis and treatment options for this unique headache disorder. At present prognosis for new daily persistent headache is considered poor with very few effective treatment options. A new treatment paradigm for new daily persistent headache based on triggering events will be suggested. The current International Classification of Headache Disorders 2 criteria for new daily persistent headache will also be discussed including its apparent inadequacies and revised criteria will be recommended.