Conflict of Interest: None.
Childhood Abuse and Migraine: Epidemiology, Sex Differences, and Potential Mechanisms
Article first published online: 1 JUN 2011
© 2011 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 51, Issue 6, pages 869–879, June 2011
How to Cite
Tietjen, G. E. and Peterlin, B. L. (2011), Childhood Abuse and Migraine: Epidemiology, Sex Differences, and Potential Mechanisms. Headache: The Journal of Head and Face Pain, 51: 869–879. doi: 10.1111/j.1526-4610.2011.01906.x
- Issue published online: 1 JUN 2011
- Article first published online: 1 JUN 2011
- Accepted for publication December 27, 2010.
- childhood maltreatment;
Migraine and maltreatment are both common conditions that are more prevalent in women. Epidemiological evidence supports an association between childhood abuse and headache, as well as pain in general, although some controversy exists based on methodological concerns of studying the influence of remote, traumatic, stigmatizing events in an often depressed population. There is a growing scientific body of knowledge regarding the neurobiological effects of abuse on brain function and structure that suggest a possible role of early life stress in the pathogenesis of migraine, and a differential impact based on sex. Advances in our understanding of the basic mechanisms by which an adverse environment interacts with and changes the genome, may suggest new treatment strategies.