Transient Global Amnesia Triggered by Migraine in Monozygotic Twins

Authors

  • Ferdinando Maggioni MD,

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  • Federico Mainardi MD,

    1. From the Department of Neurosciences, Headache Centre, University of Padua, Padova, Italy (F. Maggioni, M. Bellamio, and G. Zanchin); Department of Neurology, Headache Center, Venice, Italy (F. Mainardi).
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  • Matteo Bellamio MD,

    1. From the Department of Neurosciences, Headache Centre, University of Padua, Padova, Italy (F. Maggioni, M. Bellamio, and G. Zanchin); Department of Neurology, Headache Center, Venice, Italy (F. Mainardi).
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  • Giorgio Zanchin MD

    1. From the Department of Neurosciences, Headache Centre, University of Padua, Padova, Italy (F. Maggioni, M. Bellamio, and G. Zanchin); Department of Neurology, Headache Center, Venice, Italy (F. Mainardi).
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  • Conflict of Interest: None

F. Maggioni, Department of Neurosciences, University of Padua, Via Giustiniani 5, 35128 Padova, Italy, email: ferdinando.maggioni@unipd.it

Abstract

(Headache 2011;51:1305-1308)

Transitory global amnesia and migraine without aura are diseases with unclear pathophysiologic mechanisms, but with evidence of comorbidity. We describe twin monozygotic brothers, both presenting episodes of transitory global amnesia occurring only during attacks of migraine without aura. This report supports the hypothesis of a common underlying pathogenetic mechanism, possibly related to the cortical spreading depression. Furthermore, a common genetic trait in both the diseases or more probably in a particular subgroup of patients could be hypothesized.

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