Conflict of Interest: None.
Family-Based Association Study of Chromosome 6p12.2-p21.1 Migraine Locus
Article first published online: 21 NOV 2011
© 2011 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 52, Issue 3, pages 393–399, March 2012
How to Cite
Oterino, A., Toriello, M., Castillo, J., González-Quitanilla, V., Sánchez-Velasco, P., Alonso, A., Ruiz-Lavilla, N. and Pascual, J. (2012), Family-Based Association Study of Chromosome 6p12.2-p21.1 Migraine Locus. Headache: The Journal of Head and Face Pain, 52: 393–399. doi: 10.1111/j.1526-4610.2011.02040.x
- Issue published online: 8 MAR 2012
- Article first published online: 21 NOV 2011
- Accepted for publication August 25, 2011.
- migraine genetics;
- MIGR3 locus;
- family-based association study
Background.— One of the genome-wide linkage studies performed in migraine has yielded a significant linkage of migraine (with and without aura) with markers located at 6p12.2-21.1. This locus (named MIGR3) has not been replicated in the only genome-wide association scan study performed to date or in previous genome-wide linkage studies.
Objective.— Our objective had been to replicate the MIGR3 locus performing a family-based association study.
Methods.— A sample of 594 subjects belonging to 134 migraine families of diverse complexity underwent genotyping for the markers previously published as linked at 6p12.2-21.1 migraine locus. Family-based association test, under different models of inheritance, and also the model-free TDT analysis were performed.
Results.— The best result was obtained with the D6S1650 marker under the additive model (rank [S observed] = 265.0; permuted P = .0006), using family-based association test program (HBAT subprogram). Similar results were obtained with the model-free TDTPHASE algorithm (P < .0001, corrected). Nominal significant P values were obtained for D6S1630, D6S452, and D6S257. After correction for multiple testing with the stratified false-discovery rate, all markers showed significant association (P < .0001).
Conclusion.— We corroborated that the MIGR3 locus at 6p12 is a genetic risk for migraine with and without aura.