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Unanswered Questions in Headache: How Does a Migraine Attack Stop?

Authors

  • Andrew H. Ahn MD, PhD,

    Corresponding author
    1. From the College of Medicine, University of Florida, Gainesville, FL, USA (A.H. Ahn); University of Utah, Salt Lake City, UT, USA (K.C. Brennan).
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  • K.C. Brennan MD

    Corresponding author
    1. From the College of Medicine, University of Florida, Gainesville, FL, USA (A.H. Ahn); University of Utah, Salt Lake City, UT, USA (K.C. Brennan).
    Search for more papers by this author

  • Conflict of Interest: The authors declare that they have no conflicts of interest related to this manuscript.

A.H. Ahn, 100 South Newell Drive, Box 100236, Gainesville, FL 32610-0236, USA, email: ahn@neurology.ufl.edu or K.C. Brennan, 420 Chipeta Way, Suite 1700, Salt Lake City, UT 84108, USA, email: k.c.brennan@hsc.utah.edu

Abstract

Much research in migraine focuses on understanding its initiation. But as migraine is typically self-limited, its offset may be as important as its onset. We pose the question “how does migraine stop?” to three investigators with different backgrounds. The consensus is that the termination of a migraine attack, rather than being the passive loss of a trigger, must itself be an active biologic process.

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