Study funding: Supported through the Lundbeck Foundation Center for Neurovascular Signaling.
Nitric Oxide Modulation of Low-Frequency Oscillations in Cortical Vessels in FHM – a NIRS Study
Article first published online: 21 FEB 2012
© 2012 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 52, Issue 7, pages 1146–1154, July/August 2012
How to Cite
Schytz, H. W., Hansen, J. M., Phillip, D., Selb, J., Boas, D. A. and Ashina, M. (2012), Nitric Oxide Modulation of Low-Frequency Oscillations in Cortical Vessels in FHM – a NIRS Study. Headache: The Journal of Head and Face Pain, 52: 1146–1154. doi: 10.1111/j.1526-4610.2012.02098.x
Conflict of Interest: H.W. Schytz, J.M. Hansen, D. Phillip, J. Selb, D.A. Boas, and M. Ashina report no disclosures.
- Issue published online: 3 JUL 2012
- Article first published online: 21 FEB 2012
- Accepted for publication December 8, 2011.
- familial hemiplegic migraine;
- nitric oxide;
- low-frequency oscillation;
- cortical vessel;
- near-infrared spectroscopy
Background.— The pathophysiological alterations in patients with familial hemiplegic migraine (FHM) are not yet fully known. The headache characteristics in patients with FHM mutations have been examined in a series of glyceryl trinitrate (GTN) provocation studies in FHM patients, but the cortical vascular response to GTN in FHM patients has never been investigated before.
Objective.— To investigate changes in spontaneous low-frequency oscillations (LFO) of cortical vessels in response to the nitric oxide donor GTN by near-infrared spectroscopy in FHM patients.
Methods.— Twenty-three FHM patients without known mutations and 9 healthy controls received a continuous intravenous infusion of GTN 0.5 µg/kg/minute over 20 minutes. Using near-infrared spectroscopy, we recorded oxygenated hemoglobin (oxyHb) LFO amplitude bilateral at the frontal cortex at baseline and 15 minutes and 40 minutes after start of the GTN infusion.
Results.— GTN changed oxyHb LFO amplitude in FHM patients (P = .002), but not in healthy controls (P = .121). Only in FHM patients with coexisting common migraine types did GTN infusion induced changes in LFO amplitudes (P < .001), where post-hoc analysis revealed an increase in LFO amplitude 15 minutes (P = .003) and 40 (P = .013) minutes after start of infusion compared with baseline. Interestingly, GTN infusion induced no changes in LFO amplitude in patients with a pure FHM phenotype (P = .695).
Conclusion.— FHM patients with a mixed phenotype (coexisting common type of migraine) showed an increase in oxyHb LFO amplitude during GTN infusion, whereas FHM patients with pure phenotype showed no changes. These data suggest possible differences in frontal cortical nitric oxide vascular sensitivity between FHM patients with a mixed phenotype and patients with pure FHM.