Disclosures: Dr. Angela Applebee has served on a scientific advisory board for Teva Pharmaceuticals and is or has been involved in clinical trials sponsored by Novartis, Serono, Sanofi Aventis, Genentech/Roche, Biogen, Teva Pharmaceuticals, and Acorda.
The Clinical Overlap of Multiple Sclerosis and Headache
Article first published online: 2 OCT 2012
© 2012 American Headache Society
Headache: The Journal of Head and Face Pain
Special Issue: Proceedings of the Headache Cooperative of New England 2012 Meeting, Stowe, Vermont
Volume 52, Issue Supplement s2, pages 111–116, October 2012
How to Cite
Applebee, A. (2012), The Clinical Overlap of Multiple Sclerosis and Headache. Headache: The Journal of Head and Face Pain, 52: 111–116. doi: 10.1111/j.1526-4610.2012.02243.x
- Issue published online: 2 OCT 2012
- Article first published online: 2 OCT 2012
- Accepted for publication July 12, 2012.
- multiple sclerosis;
Multiple sclerosis (MS) and migraine headache coexist in many young female patients. Whether this is coincidental or causally linked remains unclear. The presenting symptoms and signs of MS relapse and migraine aura can be similar and should be differentiated by careful history and examination to ensure proper diagnosis and treatment. White matter lesions on magnetic resonance imaging have specific patterns for each entity and also need to be interpreted carefully. Although a clear link has not been established between migraine and MS, numerous studies have been reported assessing risks, prevalence, and causation. Complicating these assessments are the disease-modifying therapies used to treat MS which have been known to be implicated in causing headache. The recent development of novel treatment options for MS requires practitioners to be aware of polypharmacy and potential drug interactions.