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Research Submission

In Medication-Overuse Headache, fMRI Shows Long-Lasting Dysfunction in Midbrain Areas

  1. Stefania Ferraro MSc1,*,
  2. Licia Grazzi MD2,
  3. Riccardo Muffatti MD4,
  4. Simone Nava MSc1,
  5. Francesco Ghielmetti PhD1,
  6. Nicola Bertolino MSc3,
  7. Maria Luisa Mandelli PhD5,
  8. Eleonora Visintin MSc1,
  9. Maria Grazia Bruzzone MD1,
  10. Anna Nigri MSc1,
  11. Francesca Epifani BSc1,
  12. Gennaro Bussone MD2,
  13. Luisa Chiapparini MD1

Article first published online: 23 OCT 2012

DOI: 10.1111/j.1526-4610.2012.02276.x

Issue

Headache: The Journal of Head and Face Pain

Headache: The Journal of Head and Face Pain

Volume 52, Issue 10, pages 1520–1534, November/December 2012

Additional Information

How to Cite

Ferraro, S., Grazzi, L., Muffatti, R., Nava, S., Ghielmetti, F., Bertolino, N., Mandelli, M. L., Visintin, E., Bruzzone, M. G., Nigri, A., Epifani, F., Bussone, G. and Chiapparini, L. (2012), In Medication-Overuse Headache, fMRI Shows Long-Lasting Dysfunction in Midbrain Areas. Headache: The Journal of Head and Face Pain, 52: 1520–1534. doi: 10.1111/j.1526-4610.2012.02276.x

Author Information

  1. 1

    Neuroradiology Department, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy

  2. 2

    Headache Centre, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy

  3. 3

    Health Department, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy

  4. 4

    Department of Psychiatry, University of Milan Medical School and San Paolo Hospital, Milan, Italy

  5. 5

    Department of Radiology and Biomedical Imaging Center for Functional and Molecular Imaging, UCSF, San Francisco, CA, USA

*Address all correspondence to S. Ferraro, Neuroradiology Department, Foundation IRCCS Neurological Institute Carlo Besta, Milan 20133, Italy, email: stefania.ferraro@istituto-besta.it

  1. Conflict of Interest: None.

  2. Disclosure information: We declare that no financial support was provided by any company whose products may be related to the topic of this manuscript.

Publication History

  1. Issue published online: 15 NOV 2012
  2. Article first published online: 23 OCT 2012
  3. Manuscript Accepted: 19 AUG 2012

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Table S1. Regions Showing Increased BOLD Signal Changes During Decision-Making in MOH I Group, MOH II Group, CM Group and in the Control Group and Differences.

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