Genetic Variations in Tumor Necrosis Factor Alpha, Interleukin-10 Genes, and Migraine Susceptibility


  • Disclosures: The authors of this article declare no conflict of interest.

Omer Ates, PhD, Department of Medical Biology, Medical Faculty, Gaziosmanpasa University, 60100, Tokat, Turkey. Tel: + 90 356 2129500/1290; Fax: +90 356 213 31 79; E-mail:


Objectives.  Migraine is a very common headache disorder and pathogenesis of the disease is still largely unknown. Cytokine genes have been implicated in migraine susceptibility. The present study was designed to explore the associations of polymorphisms in the tumor necrosis factor alpha (TNF-α), interleukin-10 (IL-10) gene, and IL-10 haplotypes in Turkish migraine patients.

Methods.  TNF-α−308G/A, IL-10 −1082G/A, −819C/T, and −592C/A polymorphisms in 203 migraine patients and 202 healthy subjects were analyzed by using amplification refractory mutation system-polymerase chain reaction.

Results.  The −308G/A genotypic and −308A allelic frequency of TNF-α polymorphism was higher in migraine patients than healthy controls, and significant association was found between migraine and TNF-α−308G/A polymorphism (Bonferroni correction [Pc]: <0.0001, odds ratio: 2.16, 95% confidence interval: 1.44–3.28). No statistically significant association was found between IL-10 −1082G/A, −819C/T, and −592C/A polymorphisms and haplotypes containing these alleles and migraine.

Conclusions.  This study reflect that TNF-α−308G/A polymorphism may be one of the many genetic factors for migraine susceptibility in the Turkish population.