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Experimental Pain Ratings and Reactivity of Cortisol and Soluble Tumor Necrosis Factor-α Receptor II Following a Trial of Hypnosis: Results of a Randomized Controlled Pilot Study

Authors

  • Burel R. Goodin PhD,

    Corresponding author
    1. University of Florida, Comprehensive Center for Pain Research, Gainesville, Florida
      Burel Goodin, PhD, University of Florida College of Dentistry, 1395 Center Drive, Dental Tower, Room D2-13, Gainesville, FL 32610, USA. Tel: 352-273-8934; Fax: 352-273-6945; E-mail: bgoodin1@ufl.edu.
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  • Noel B. Quinn MA,

    1. Department of Psychology, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland
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  • Tarek Kronfli BA,

    1. Alliant International University, California School of Professional Psychology-San Francisco, San Francisco, California
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  • Christopher D. King PhD,

    1. University of Florida, Comprehensive Center for Pain Research, Gainesville, Florida
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  • Gayle G. Page DNSc,

    1. Center for Nursing Research, Johns Hopkins University School of Nursing, Baltimore, Maryland
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  • Jennifer A. Haythornthwaite PhD,

    1. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University-Bayview Campus, Baltimore, Maryland
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  • Robert R. Edwards PhD,

    1. Brigham and Women's Hospital & Harvard University School of Medicine, Anesthesiology, Perioperative and Pain Medicine, Chestnut Hill, Massachusetts, USA
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  • Laura M. Stapleton PhD,

    1. Department of Psychology, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland
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  • Lynanne McGuire PhD

    1. Department of Psychology, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland
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  • Conflict of Interest Statement: There are no conflicts of interest, or any financial interests, to report with regard to this work for any of the authors.

Burel Goodin, PhD, University of Florida College of Dentistry, 1395 Center Drive, Dental Tower, Room D2-13, Gainesville, FL 32610, USA. Tel: 352-273-8934; Fax: 352-273-6945; E-mail: bgoodin1@ufl.edu.

Abstract

Objective.  Current evidence supports the efficacy of hypnosis for reducing the pain associated with experimental stimulation and various acute and chronic conditions; however, the mechanisms explaining how hypnosis exerts its effects remain less clear. The hypothalamic–pituitary–adrenal (HPA) axis and pro-inflammatory cytokines represent potential targets for investigation given their purported roles in the perpetuation of painful conditions; yet, no clinical trials have thus far examined the influence of hypnosis on these mechanisms.

Design.  Healthy participants, highly susceptible to the effects of hypnosis, were randomized to either a hypnosis intervention or a no-intervention control. Using a cold pressor task, assessments of pain intensity and pain unpleasantness were collected prior to the intervention (Pre) and following the intervention (Post) along with pain-provoked changes in salivary cortisol and the soluble tumor necrosis factor-α receptor II (sTNFαRII).

Results.  Compared with the no-intervention control, data analyses revealed that hypnosis significantly reduced pain intensity and pain unpleasantness. Hypnosis was not significantly associated with suppression of cortisol or sTNFαRII reactivity to acute pain from Pre to Post; however, the effect sizes for these associations were medium-sized.

Conclusions.  Overall, the findings from this randomized controlled pilot study support the importance of a future large-scale study on the effects of hypnosis for modulating pain-related changes of the HPA axis and pro-inflammatory cytokines.

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