Financial support: Dr. Shaw and Dr. Buchheit are supported by the Congressionally Directed Medical Research Programs and the Department of Defense(DM102142). Dr. Van de Ven is supported by T32 NIH grant# 2T32GM008600.
Original Research Article
Epigenetics and the Transition from Acute to Chronic Pain
Article first published online: 14 SEP 2012
Wiley Periodicals, Inc.
Volume 13, Issue 11, pages 1474–1490, November 2012
How to Cite
Buchheit, T., Van de Ven, T. and Shaw, A. (2012), Epigenetics and the Transition from Acute to Chronic Pain. Pain Medicine, 13: 1474–1490. doi: 10.1111/j.1526-4637.2012.01488.x
Conflict of interest/disclosure: The authors report no conflicts of interest.
- Issue published online: 14 NOV 2012
- Article first published online: 14 SEP 2012
- DNA Methylation;
- Histone Deacetylase Inhibitors;
- RNA Interference
Objective. The objective of this study was to review the epigenetic modifications involved in the transition from acute to chronic pain and to identify potential targets for the development of novel, individualized pain therapeutics.
Background. Epigenetics is the study of heritable modifications in gene expression and phenotype that do not require a change in genetic sequence to manifest their effects. Environmental toxins, medications, diet, and psychological stresses can alter epigenetic processes such as DNA methylation, histone acetylation, and RNA interference. As epigenetic modifications potentially play an important role in inflammatory cytokine metabolism, steroid responsiveness, and opioid sensitivity, they are likely key factors in the development of chronic pain. Although our knowledge of the human genetic code and disease-associated polymorphisms has grown significantly in the past decade, we have not yet been able to elucidate the mechanisms that lead to the development of persistent pain after nerve injury or surgery.
Design. This is a focused literature review of epigenetic science and its relationship to chronic pain.
Results. Significant laboratory and clinical data support the notion that epigenetic modifications are affected by the environment and lead to differential gene expression. Similar to mechanisms involved in the development of cancer, neurodegenerative disease, and inflammatory disorders, the literature endorses an important potential role for epigenetics in chronic pain.
Conclusions. Epigenetic analysis may identify mechanisms critical to the development of chronic pain after injury, and may provide new pathways and target mechanisms for future drug development and individualized medicine.