This work was presented in part at the American Epilepsy Society Meeting, Baltimore, Maryland, December 1987, and published in abstract form in Epilepsia 1987;27:626.
Efficacy of the Ketogenic Diet for Intractable Seizure Disorders: Review of 58 Cases
Article first published online: 4 AUG 2005
Volume 33, Issue 6, pages 1132–1136, November 1992
How to Cite
Kinsman, S. L., Vining, E. P. G., Quaskey, S. A., Mellits, D. and Freeman, J. M. (1992), Efficacy of the Ketogenic Diet for Intractable Seizure Disorders: Review of 58 Cases. Epilepsia, 33: 1132–1136. doi: 10.1111/j.1528-1157.1992.tb01770.x
- Issue published online: 4 AUG 2005
- Article first published online: 4 AUG 2005
- Received August 1991; revision accepted February 1992.
- Diet therapy-Dietary fats;
- Ketone bodies;
Summary: The ketogenic diet was developed in the 1920s as a treatment for intractable childhood seizures when few antiepileptic drugs (AEDs) were available. There are still children whose seizures are refractory even to modern therapy, but use of the ketogenic diet appears to be waning. At Johns Hopkins, we continue to believe that the diet is very effective and well accepted by patients and families. To reevaluate our opinion of the efficacy and acceptability of this form of therapy in patients cared for in the 1980s with the newer AEDs, we analyzed the records of 58 consecutive patients who had been started on the diet. Before using the diet, 80% of the patients had multiple seizure types and 88% were treated with multiple AEDs; these children were among our most intractable patients. Despite this, seizure control improved in 67% of patients with the ketogenic diet, and actuarial analysis indicated that 75% of these improved patients continued the diet for at least 18 months. Sixty-four percent had AEDs reduced, 36% became more alert, and 23% had improved behavior. The improvement in these patients with intractable seizures and the length of time that families maintained the regimen indicate that the ketogenic diet continues to have a very useful therapeutic role in selected patients and their families.