Degree of Hippocampal Neuron Loss Determines Severity of Verbal Memory Decrease After Left Anteromesiotemporal Lobectomy
Article first published online: 3 AUG 2005
Volume 35, Issue 6, pages 1179–1186, November 1994
How to Cite
Sass, K. J., Westerveld, M., Buchanan, C. P., Spencer, S. S., Kim, J. H. and Spencer, D. D. (1994), Degree of Hippocampal Neuron Loss Determines Severity of Verbal Memory Decrease After Left Anteromesiotemporal Lobectomy. Epilepsia, 35: 1179–1186. doi: 10.1111/j.1528-1157.1994.tb01786.x
- Issue published online: 3 AUG 2005
- Article first published online: 3 AUG 2005
- Received December 1993; revision accepted January 1994.
- Temporal lobe epilepsy;
- Neuron loss;
- Verbal memory;
- Temporal lobectomy;
- Neuropsychological tests
Summary: Fifty-eight left speech dominant adults with medically refractory epilepsy originating from the temporal lobe (28 left, 30 right) were examined using the verbal Selective Reminding Test before and after anteromesiotemporal lobectomy. After neuron density in the excised hippocampal tissue was established, a median split procedure was performed to distinguish patients with severe neuron loss (13 left, 16 right) from those with only mild or moderate neuron loss (15 left, 14 right). The memory of patients with severe left hippocampal neuron loss did not decrease significantly postoperatively. Patients with mild or moderate left hippocampal neuron loss experienced significant verbal memory decrease postoperatively. The magnitude of the verbal memory decrease was not related to recurrence of seizures after operation. Patients undergoing right anteromesiotemporal lobectomy exhibited significant improvements in verbal memory, regardless of the condition of the excised hippocampal tissue. The degree of hippocampal neuron loss determines to a great extent the severity of the verbal memory decrease that follows dominant anteromesiotemporal lobectomy.