Liver Enzyme Induction and Serum Lipid Levels After Replacement of Carbamazepine with Oxcarbazepine
Version of Record online: 3 AUG 2005
Volume 35, Issue 6, pages 1217–1220, November 1994
How to Cite
Isojärvi, J. I. T., Pakarinen, A. J., Rautio, A., Pelkonen, O. and Myllylä, V. V. (1994), Liver Enzyme Induction and Serum Lipid Levels After Replacement of Carbamazepine with Oxcarbazepine. Epilepsia, 35: 1217–1220. doi: 10.1111/j.1528-1157.1994.tb01792.x
- Issue online: 3 AUG 2005
- Version of Record online: 3 AUG 2005
- Received September 1993; revision accepted December 1993.
- Liver enzyme induction;
Summary: We evaluated liver P450 enzyme system induction and serum lipid levels in a prospective follow–up study in 12 male patients with epilepsy after replacing carbamazepine (CBZ) medication with oxcarbazepine (OCBZ). Antipyrine1 1/2 increased and antipyrineCL decreased 2 months after the medication was changed, reflecting normalization of liver P450 enzyme system function. Furthermore, serum total cholesterol levels decreased, but serum concentrations of high-density lipoprotein (HDL)-cholesterol and triglycerides (TG) were unchanged. OCBZ may be the preferable antiepileptic drug (AED) with regard to the effects of the medication on lipid metabolism.