Disposition of Carbamazepine and Phenytoin in Pregnancy
Article first published online: 20 SEP 2006
Volume 35, Issue 1, pages 131–135, January 1994
How to Cite
Tomson, T., Lindbom, U., Ekqvist, B. and Sundqvist, A. (1994), Disposition of Carbamazepine and Phenytoin in Pregnancy. Epilepsia, 35: 131–135. doi: 10.1111/j.1528-1157.1994.tb02922.x
- Issue published online: 20 SEP 2006
- Article first published online: 20 SEP 2006
- Received October 1992; revision accepted January 1993.
Summary: Free and total plasma concentrations of phenytoin (PHT) and carbamazepine (CBZ) and its active metabolite carbamazepine-10,11-epoxide (CBZ-E) were determined in a prospective study of 86 pregnant epileptic women. The pharmacokinetics of PHT and CBZ during the three trimesters were compared with kinetics at least 10 weeks postpartum. Plasma clearance and unbound CBZ clearance were slightly decreased during the last trimester. Total and free plasma CBZ-E concentrations did not change significantly during pregnancy. Plasma PHT clearance, on the other hand, increased from the first trimester. A less pronounced increase was observed for clearance of unbound PHT; the increase was statistically significant only during the third trimester.